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英國(guó)癌癥研究人員完整名錄494—6

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Insall, Professor Robert r.insall**[ta]**tson.gla.ac.uk

The actin cytoskeleton in cell movement and invasion: SCAR/W****E, WASH and chemotaxis from Dictyostelium to melanoma.Cancer Research UK Beatson Institute 01/12/2012 30/11/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Bo***

Irving, Dr Julie j.a.e.irving**[ta]**.ac.uk

Preclinical evaluation of selumetinib and glucocorticoid combination therapy for the treatment of Ras pathway positive, high risk acute lymphoblastic leukaemia Newcastle University 01/08/2014 31/10/2015 New Agents Committee - PreClinical Grants New Agents Committee

Ismail, Dr Shehab Structural Biology of Cilia Cancer Research UK Beatson Institute 01/01/2014 31/12/2020 Scientifc Executive Board - Institute Group Award Scientifc Executive Bo***

Jackson, Professor Alan CRUK & EPSRC Cancer Imaging Centre in Cambridge & Manchester University of Manchester 01/12/2013 30/11/2018 Scientifc Executive Board - Cancer Imaging Centres Scientifc Executive Board

Jackson, Dr Andrew Andrew.Jackson**[ta]**.nhs.uk

CRUKD/11/012: ROCOCO: A phase I dose escalation trial of Radiotherapy and Olaparib (a PARP1 inhibitor), in combination for carcinoma of the oesophagus Christie NHS Foundation Trust 01/01/2014 30/09/2016 New Agents Committee - Trial Grant Application New Agents Committee

Jackson, Professor Stephen s.jackson**[ta]**don.cam.ac.uk

Cellular responses to DNA damage University of Cambridge 01/10/2010 30/09/2015 Science Committee - Programme Award Science Committee

Jacobs, Professor Ian i.jacobs**[ta]**w.edu.au Risk Stratifcation, Early Detection and Diagnosis of Ovarian Cancer University of Manchester 01/09/2011 31/08/2017 Population Research Committee - Programme Award Population Research CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Committee

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.James, Professor Nicholas CRUK/09/021: TUXEDO - Phase I/II feasibility study of cetuximab with or without cisplatin with concurrent radiotherapy in muscle invasive bladder cancer University of Birmingham 01/02/2010 29/02/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUK/06/019: STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efcacy.A three-stage multi-arm, randomised controlled trial University College London 01/10/2006 30/09/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Jankowski, Professor Janusz janusz.jankowski**[ta]**w.nhs.uk

CRUK/05/006: ASPECT: Aspirin esomeprazole chemoprevention trial University of Oxford 01/01/2005 31/08/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Jodrell, Professor Duncan duncan.jodrell**[ta]**k.cam.ac.uk

CRUKD/10/028 A Cancer Research UK Phase I trial of MK0752, an oral notch inhibitor, alone or in combination with gemcitabine in locally advanced or metastatic pancreatic cancer Addenbrooke's Hospital 01/04/2008 30/09/2015 New Agents Committee - DD Project Proposal New Agents Committee

Preclinical combination studies with AZD2014 (mTORi) and Olaparib (AZD2281) University of Cambridge 01/02/2014 31/10/2015 New Agents Committee - PreClinical Grants New Agents Committee

Pharmacology and Drug Development Laboratory Cancer Research UK Cambridge Institute 01/11/2012 31/10/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Joﬀe, Professor Johnathan CRUK/07/020: TRISST: A randomised phase III trial of imaging and schedule in Seminoma Testis (MRCTE24) University College London 01/10/2007 30/09/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Johnson, Professor Peter CRUKE/10/024: REMoDL-B: A Randomised Evaluation of Molecular guided therapy for Diﬀuse Large B-cell Lymphoma with Bortezomib University of Southampton 01/10/2010 30/09/2015 Clinical Trials Awards & Advisory Committee - Endorsement - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/07/033: RATHL: A randomised trial to assess Response Adapted Therapy using FDG-PET imaging in patients with advanced Hodgkin Lymphoma.University College London 01/05/2008 30/04/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Johnston, Professor Patrick p.johnston**[ta]**.ac.uk

Identifcation and targeting of clinically relevant molecular and genetic subtypes in colorectal cancer (Supported by the Bobby Moore Fund for CRUK, from May 2014) Queen's University Belfast 01/08/2012 31/07/2017 Science Committee - Programme Award Science Committee

Jones, Professor E.Yvonne The structural biology of recognition and signalling at the cell surface.University of Oxford 01/10/2014 30/09/2019 Science Committee - Programme Award Science Committee

Jones, Professor Nic nic.jones**[ta]**k.manchester.ac.uk

Cell Regulation Group Cancer Research UK Manchester Institute 01/04/2007 30/11/2015 Biological Sciences Committee - Institute Group Award Science Committee

Jones, Dr Philip phj20**[ta]**-cu.cam.ac.uk

Clonal evolution in oesophageal squamous preneoplasia Wellcome Trust Sanger Institute 01/07/2014 30/06/2019 Science Committee - Programme Award Science CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

CTU QQR CR-UK Clinical Trials Unit Glasgow Beatson West of Scotland Cancer Centre Glasgow University of Glasgow 01/10/2013 30/09/2018 Clinical and Translational Research Committee - Clinical Trials Unit - Programme Award Clinical Trials Awards & Advisory Committee

Investment to support purchase of electronic remote data capture (eRDC) system for clinical trials University of Glasgow 01/02/2015 31/07/2016 Clinical and Translational Research Committee - Clinical Trials Unit - Programme Award Clinical Trials Awards & Advisory Committee

A clinical research fellowship in cancer clinical trials University of Glasgow 01/08/2015 31/07/2017 Clinical Trials Awards & Advisory Committee - Clinical Trial Fellowship Clinical Trials Awards & Advisory Committee

CRUKE/12/032: MAdCaP - Mdm2 inhibition and Abiraterone in Carcinoma of the Prostate - a randomized phase II trial of abiraterone acetate with or without RO5503781 in patients with mCRPC who have not previously received docetaxel University of Glasgow 01/07/2014 30/06/2018 Clinical Trials Awards & Advisory Committee - Endorsement - Feasibility Study Clinical Trials Awards & Advisory Committee

Jorgensen, Dr Claus Claus.Jorgensen**[ta]**k.manchester.ac.uk

Analysis of reciprocal tumour-stroma signalling in pancreatic cancer.University of Manchester 01/08/2011 30/09/2017 New Investigator Committee - Career Establishment Award New Investigator Committee

Systems Oncology University of Manchester 01/01/2014 31/12/2018 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Judson, Professor Ian CRUK/10/021: CASPS: A phase II study of Cediranib (AZD2171) in Alveolar Soft Part Sarcoma (AZ/NCRN) Institute of Cancer Research 01/10/2010 31/01/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Kamphorst, Dr Jurre jurre.kamphorst**[ta]**sgow.ac.uk

The eﬀect of tumour microenvironment on the metabolism of pancreatic cancer cells University of Glasgow 01/12/2014 30/11/2020 New Investigator Committee - Career Development Fellowship New Investigator Committee

Karran, Dr Peter Mammalian DNA Damage Repair Laboratory The Francis Crick Institute 01/11/2010 31/10/2015 Biological Sciences Committee - Institute Group Award Science Committee

Katan, Professor Matilda m.katan**[ta]**.ac.uk

FGFR family and their eﬀectors in cancer University College London 01/10/2013 30/09/2018 Science Committee - Programme Award Science Committee

Kearns, Professor Pamela p.r.kearns**[ta]**m.ac.uk

Cancer Research UK Clinical Trials Unit (CRCTU) University of Birmingham 01/10/2013 30/09/2018 Clinical and Translational Research Committee - Clinical Trials Unit - Programme Award Clinical Trials Awards & Advisory Committee

CRCTU Clinical Trial Fellowship University of Birmingham 01/08/2015 31/07/2017 Clinical Trials Awards & Advisory Committee - Clinical Trial Fellowship Clinical Trials Awards & Advisory Committee

Kelsell, Professor David d.p.kelsell**[ta]**l.ac.uk

iRHOM/ADAM17 in oesophageal squamous cell cancer Queen Mary, University of London 01/04/2015 31/03/2020 Science Committee - Programme Award Science Committee

Key, Professor Timothy tim.key**[ta]**.ox.ac.uk

The epidemiology and aetiology of high risk prostate cancer University of Oxford 01/04/2015 31/03/2020 Population Research Committee - Programme Award Population Research CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

Cancer Research UK stress response laboratory University of Dundee 01/10/2010 30/09/2016 Science Committee - Programme Award Science Committee

Khaled, Dr Walid wtk22**[ta]**.ac.uk

Cellular and Molecular Characterisation of Breast Cancer Heterogeneity University of Cambridge 01/10/2014 30/09/2020 New Investigator Committee - Career Establishment Award New Investigator Committee

Khaw, Professor Kay-Tee kk101**[ta]**schl.cam.ac.uk

Lifestyle and biological determinants of cancer: the European Prospective Investigation into Cancer in Norfolk population study University of Cambridge 01/04/2012 31/03/2017 Population Research Committee - Programme Award Population Research Committee

Khiroya, Dr Heena Iron homeostasis as a potential modulator of cellular proliferation and prognosis in non small cell lung cancer University of Birmingham 01/08/2015 31/07/2016 Clinical Careers Committee - Research Bursary Clinical Careers Committee

Kiltie, Dr Anne anne.kiltie**[ta]**ology.ox.ac.uk

The role of DNA repair in the aetiology of bladder cancer and its response to radiotherapy and combined modality treatments Cancer Research UK/ MRC Oxford Institute for Radiation Oncology 01/10/2009 30/09/2016 Biological Sciences Committee - Institute Group Award Science Committee

Investigating the potential for synergistic radiosensitisation of bladder cancer by gemcitabine and the PARP inhibitor olaparib University of Oxford 01/10/2014 30/09/2016 New Agents Committee - PreClinical Grants New Agents Committee

Kimata, Dr Yuu yk299**[ta]**.ac.uk

Investigation of the roles for the APC/C in the cell cycle control of the centrosome activity and integrity and its spatiotemporal regulation on the centrosome University of Cambridge 01/11/2011 31/10/2017 New Investigator Committee - Career Development Fellowship New Investigator Committee

King, Dr Emma e.king**[ta]**on.ac.uk

CRUK/11/047: COAST (Cisplatin Ototoxicity attenuated by ASpirin Trial): A phase II randomised controlled trial of aspirin in the preventative role of cisplatin induced ototoxicity University of Southampton 01/03/2012 31/10/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Immune response evaluation as a prognostic tool in HPV-positive oropharyngeal cancer University of Southampton 01/01/2014 30/06/2016 Science Committee - Biomarker Project Award Science Committee

Koh, Dr Dow-Mu Quantitative diﬀusion-weighted MR imaging of microcapillary perfusion and tissue diﬀusivity as biomarkers of response to sunitinib treatment in renal cell carcinoma Institute of Cancer Research 01/09/2010 31/01/2016 Science Committee - Biomarker Project Award Science Committee

Kouskoﬀ, Dr Valerie valerie.kouskoﬀ**[ta]**k.manchester.ac.uk

Stem cell & haematopoiesis Cancer Research UK Manchester Institute 01/01/2010 30/09/2015 Biological Sciences Committee - Institute Group Award Science Committee

Kouzarides, Professor Tony t.kouzarides**[ta]**don.cam.ac.uk

Function of Chromatin Modifcations and their Role in Cancer University of Cambridge 01/05/2014 30/04/2019 Science Committee - Programme Award Science Committee

Kranc, Professor Kamil kamil.kranc**[ta]**ac.uk

Hypoxia signalling pathways in normal and leukaemic stem cell functions University of Edinburgh 01/03/2013 28/02/2019 New Investigator Committee - Senior Cancer Research Fellowship New Investigator CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

CRUK/13/008: A Single Arm Phase II trial of BMN673 for inoperable, advanced endometrial cancer with retrospective PTEN, MSI and MRE11 analysis (Supported by Stand Up To Cancer) University College London 01/11/2014 31/10/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

La Thangue, Professor Nicholas nick.lathangue**[ta]**ology.ox.ac.uk

The Cancer Cell Cycle: Control of pRb and p53 tumour suppressor proteins University of Oxford 01/10/2011 30/09/2016 Science Committee - Programme Award Science Committee

Lacaud, Dr Georges georges.lacaud**[ta]**k.manchester.ac.uk

Stem Cell Biology Cancer Research UK Manchester Institute 01/01/2010 30/09/2015 Biological Sciences Committee - Institute Group Award Science Committee

Landau, Dr David CRUK/14/027: SARON: Stereotactic Ablative Radiotherapy for Oligometastatic Non-small cell lung cancer: a randomised phase III trial University College London 01/09/2015 31/08/2020 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Langley, Dr Ruth CRUK/12/033: Add-Aspirin Trial- A phase III doubleblind placebo-controlled randomized trial assessing the addition of aspirin after standard primary therapy in early stage common solid tumours University College London 01/09/2013 31/08/2025 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/14/039 Prospective sample collection for translational research within the Add-Aspirin trial University College London 01/07/2015 30/06/2025 Clinical Trials Awards & Advisory Committee - Sample Collection Clinical Trials Awards & Advisory Committee

Larkin, Dr James james.larkin**[ta]**.nhs.uk

CRUKE/11/061: A-PREDICT - A Phase II Study Of Axitinib in Patients with Metastatic Renal Cell Cancer Unsuitable for Nephrectomy Institute of Cancer Research 01/05/2012 30/04/2017 Clinical Trials Awards & Advisory Committee - Endorsement - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUK/14/036 PERM: A Randomised Phase II Study Assessing Enhancement of Response to MK3475 by High Dose Palliative Radiotherapy in Patients with Advanced Melanoma Royal Marsden NHS Foundation Trust 01/07/2015 30/06/2019 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

Leach, Professor Martin martin.leach**[ta]**.ac.uk

CRUK Cancer Imaging Centre at ICR.Institute of Cancer Research 01/12/2013 30/11/2018 Scientifc Executive Board - Cancer Imaging Centres Scientifc Executive Board

Ledermann, Professor Jonathan j.ledermann**[ta]**.ac.uk

Cancer Research UK and UCL Cancer Trials Centre for clinical research in cancer through the development, conduct and analysis of clinical trials University College London 01/10/2013 30/09/2018 Clinical and Translational Research Committee - Clinical Trials Unit - Programme Award Clinical Trials Awards & Advisory Committee

CRUK/07/025: ICON6: An international randomised trial of molecular targeted therapy with AZD2171 with Pt-based chemotherapy for patients with ovarian cancer relapsing more than 6 months following completion of frst line Pt-based University College London 01/07/2007 30/06/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The role of the Bone Morphogenetic Protein (BMP) pathway in the pathogenesis of inherited and sporadic colorectal cancers University of Oxford 01/01/2014 31/12/2017 Clinical Careers Committee - Clinician Scientist Fellowship Clinical Careers Committee

Leigh, Professor Irene i.m.leigh**[ta]**dee.ac.uk

Non melanoma skin cancer from the laboratory to the clinic: Cancer Research UK Skin Tumour Laboratory University of Dundee 01/10/2011 30/09/2016 Science Committee - Programme Award Science Committee

Lemoine, Professor Nick bci-director**[ta]**l.ac.uk

Genomics & Molecular Pathology of Pancreatic Cancer Queen Mary, University of London 01/10/2010 31/05/2016 Science Committee - Programme Award Science Committee

Lester, Dr Jason jason.lester2**[ta]**es.nhs.uk

CRUK/10/005: I-START: ISoToxic Accelerated Radiotherapy for Non-small cell lung cancer.Velindre NHS Trust 01/07/2010 30/06/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

Leung, Professor Hing h.leung**[ta]**tson.gla.ac.uk

Urology Research Group Cancer Research UK Beatson Institute 01/08/2011 31/07/2016 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Lilley, Professor David d.m.j.lilley**[ta]**dee.ac.uk

The Cancer Research-UK Nucleic Acid Structure Research Group : Nucleic acid structure and interactions with proteins University of Dundee 01/01/2011 31/12/2015 Science Committee - Programme Award Science Committee

Lim, Mr Eric e.lim**[ta]**t.nhs.uk

CRUK/12/030: MARS 2- A study to determine if it is feasible to recruit into a randomised trial comparing extended pleurectomy decortication versus no extended pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma Royal Brompton & Harefeld NHS Foundation Trust 01/04/2013 31/03/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

Lim, Dr Sean s.h.lim**[ta]**on.ac.uk

Understanding and boosting T-cell transfer therapy in cancer with immunostimulatory antibodies University of Southampton 01/04/2013 30/09/2017 Clinical Careers Committee - Clinician Scientist Fellowship Clinical Careers Committee

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